If you dream about the safe, then such dream indicates your desire to hide something. Perhaps there is something you wish to hide, therefore you dream about the safe. The dream could also show that you have some walls that build in order to protect yourself from the harm that other people can cause you. If you are removing some item out of safe, it could either mean that you feel relieved and no longer need to hide something, or it could mean that you have to reveal your secrets.
Read more about dreaming of Safe in other dream meanings interpretations.